Research Faculty

Shmuel Yaccoby, Ph.D.
Associate Professor of Medicine and Physiology

Ph.D., Department of Animal Science, The Hebrew University of Jerusalem, Israel
Post –doctoral study at the Department of Physiology-Biophysics, University of Arkansas for Medical Sciences
Research Fellow, Myeloma and Transplantation Research Center, University of Arkansas for Medical Sciences
Research interest: Dr. Yaccoby seeks to elucidate the roles of various cells in the bone marrow microenvironment, such as bone and neovascular endothelial cells, in the pathogenesis of multiple myeloma. He is also studying the interaction between human hematopoietic stem cells and bone cells.

Selected Publications:

Yaccoby S, Ling W, Zhan F, Walker R, Barlogie B, Shaughnessy, JD Jr: Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple growth in-vivo. Blood 109:2106-11, 2007.

Yaccoby S, Wezeman MJ, Henderson A, Fox MH, Qing Y, Barlogie B, Epstein J: Cancer and the microenvironment: Myeloma-osteoclast interactions as a model. Cancer Res. 64: 2016-2023, 2004.

Yata K, Yaccoby S: The SCID-rab model: a novel in vivo system for primary human myeloma demonstrating growth of CD138-expressing malignant cells. Leukemia 18: 1891-1897, 2004.

Yaccoby S: The phenotypic plasticity of myeloma plasma cells as expressed by dedifferentiation into an immature, resilient, apoptosis-resistant phenotype. Clinical Cancer Research. 11: 7599-7606, 2005. 

Yaccoby S, Wezeman MJ, Zangari M, Walker R, Cottler-Fox M, Gaddy D, Ling W, Saha R, Barlogie B, Tricot G, Epstein J: Inhibitory effects of osteoblasts and increased bone formation on myeloma in novel culture systems and a myelomatous mouse model. Haematologica. 91: 192-199, 2006.

Ge Y, Zhan F, Barlogie B, Epstein B, Shaughnessy J, Yaccoby S: Fibroblast activation protein (FAP) is upregulated in myelomatous bone and supports myeloma cell survival. Br J Haematol. 133: 83-92, 2006.

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