Clinical Faculty

Frits van Rhee, M.D., Ph.D. MRCP (UK), FRCPath
Professor of Medicine, Director of Clinical Research - Myeloma Institute

Research Interest: Immunotherapy
M.D. Erasmus University of Rotterdam, Netherlands
Ph.D. University of London
Visiting Associate at National Institutes of Health, 8/96 -5/98
Fellow in Hematology & Research Fellow, Hammersmith Hospital & Royal Postgraduate Medical School, London, UK, 6/92 - 8/96
Registrar Fellow in Hematology, John Radcliffe University Hospital, Oxford, UK, 2/91 - 5/92
Registrar Fellow in Hematology, University Hospital, Nottingham, UK, 2/90 - 1/91
Residencies from 8/86 to 2/90 at Queen Elizabeth Hospital in Gateshead, UK and Macclesfiedl District General Hospital, Macclesfield, UK

Selected Publications:

1. Batchu RB,  Moreno AM, Szmania SM,  Bennet GW, Spagnoli GC, Ponnazhagan S, Barlogie B, Tricot, G,  van Rhee F.  Protein Transduction of Dendritic Cells for NY-ESO-1 Based Immunotherapy of  Myeloma. Cancer Research. Cancer 65 2005 (21), Nov 1.

2. van Rhee, F., Szmania, S., Zhan, F., Gupta, S., Pomtree, M., Lin, P., Batchu, R., Moreno, A., Spagnoli, G., Shaughnessy, J., Tricot, G.NY-ESO-1 is highly expressed in poor prognosis multiple myeloma and induces spontaneous humoral and cellular immune responses. Blood 2005; 105:3939-3944.

3. Szmania S,  Yi Q ,  Cottler-Fox M,   Rosen NA, Freeman J,  Kordsmeier BJ, A Moreno A, Shi J,   Barlogie B, Tricot G, van Rhee F. Clinical grade, myeloma antigen pre-loaded, dendritic cell vaccines retain potency after cryopreservation. Cytotherapy 2005; 7: 1-11

4. Tricot G, Barlogie B, van Rhee F.  Treatment Advances in Multiple Myeloma. British Journal of Haematology. 2004; 125: 24-30.

5. Batchu RB, Moreno AM, Szmania S, Gupta SK, Zhan F, Rosen N, Kozlowski M, Spencer T, Spagnoli GC, Shaughnessy J, Barlogie B,Tricot G, van Rhee F. High-level expression of cancer/testis antigen NY-ESO-1 and human granulocyte-macrophage colony-stimulating factor in dendritic cells with a bicistronic retroviral vector. Hum Gene Therapy. 2003; 14:1333-45.

6. Szmania S, Arthur A, Galloway A, Bruorton M, Nga TA, Henslee-Downey PJ, van Rhee F. Rapid isolation and expansion of CMV specific T-lymphocytes to clinical scale with HLA-tetramers and dendritic cells. Blood 2001; 98:505-512.

7. Susann Szmania, Guido Tricot, Frits van Rhee. NY-ESO-1 immunotherapy for multiple myeloma. Leukemia & Lymphoma, October 2006; 47(10): 2037-2048

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