Associated Faculty

Ralph Sanderson, Ph.D.
Professor of Pathology
University of Alabama at Birmingham

Ph.D., University of Alabama, Birmingham, Alabama
Postdoctoral training (biochemistry/cell biology), Stanford University School of Medicine, Stanford, California
Research interest: The goal of our research is to understand how heparan sulfate proteoglycans regulate the development and progression of multiple myeloma.

Yang, Y., Yaccoby, S., Liu, W., Langford, J.K., Pumphrey, C.Y., Theus, A., Epstein, J. and Sanderson, R.D. 2002. Soluble syndecan-1 promotes growth of myeloma tumors in vivo. Blood. 100:610-617.

Kelly, T., Miao, H-Q., Yang, Y., Navarro, E., Kussie, P., Huang, Y., MacLeod, V., Casciano, J., Joseph, L., Zhan, F., Zangari, M., Barlogie, B., Shaughnessy, J. and Sanderson, R.D. 2003.  High heparanase activity in multiple myeloma is associated with elevated microvessel density.  Cancer Res. 63: 8749-8756.

Yang, Y., Macleod, V., Bendre, M., Huang, Y., Theus, A.M., Miao, H.Q., Kussie, P., Yaccoby, S., Epstein, J., Suva, L.J., Kelly, T. and Sanderson, R.D. 2005. Heparanase promotes the spontaneous metastasis of myeloma cells to bone.  Blood  105:1303-1309.

Sanderson, R.D., Yang, Y., Kelly, T., MacLeod, V., Dai, Y. and A. Theus.  2005. Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment:  Growth regulation and the prospect of new cancer therapies.  J. Cell. Biochem. 96:897-905.

Dai, Y., Yang, Y., MacLeod, V., Yue, X., Rapraeger, A.C., Shirver, Z, Venkataraman, G., Sasisekharan, R. and Sanderson, R.D. 2005. HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo. J. Biol. Chem. 280:40066-40073.
 

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