The Myeloma Institute Treats Multiple Myeloma Patients From All Over the World
The Myeloma Institute is an international leader in the treatment and study of multiple myeloma and related diseases and one of the largest referral centers in the world. With a team of dynamic scientists and clinicians, the Myeloma Institute translates advances in the laboratory to novel clinical treatments. The hallmark of the Myeloma Institute is a program of clinical trials that challenge the traditional body of thought on disease treatment in order to improve outcomes.
Click here for clinical trials offered at the Myeloma Institute.
Superior clinical outcomes have been achieved at the Myeloma Institute through the "Total Therapy" approach, incorporating upfront tandem transplants. Outcomes have improved through the years with the incorporation of new agents such as thalidomide and bortezomib for consolidation and salvage therapies. Click here for graphs. Click here for a presentation on Treatment Approach at the Myeloma Institute.
MIRT utilizes information from Gene Array Analysis for patient management and planning of therapy.
The Myeloma Institute reported our Total Therapy outcome data at the 2008 ASCO meeting. Results indicated that Total Therapy 3 (TT3) had improved results in the 85% of patients with low-risk myeloma, as defined by gene expression profiling (GEP). Thus, at 4 years from start of protocol therapy, 85% are estimated to be alive and 80% event-free; of the 70% entering complete remission (CR), almost 90% remain in CR at 4 years. This contrasts with less than one-half of the 15% with high-risk myeloma for these 3 endpoints.
We concluded from these data, as also portrayed in Dr. Barlogie's presentation (see below), that it will be difficult to improve upon TT3 in low-risk disease, while high-risk patients need to have a substantive change in treatment direction.
Consequently, we are now employing risk-adapted therapy using our very robust GEP predictive model.
Click here to read more about the data and our conclusions.
Click here to view the UAMS Myeloma Institute presentations by Dr. Bart Barlogie and colleagues.
Painted Chromosomes in Cancer: The Book of Life in Disarray
Click here to read about this important myeloma research.
Click here for a larger image of Picture A.
Click here for a larger image of Picture B1.
Click here for a larger image of Picture B2.
Thalidomide Continues to Show Benefits Against Myeloma Click here for the story.
UAMS Performs Record 7,000th Myeloma Stem-Cell Transplant Click here for the story.
Part two: Living with Multiple Myeloma
Click here for the story
Myeloma: Quest for CR May Be Misplaced
Click here for the story
For 10 years, artist Cathy Joyce has been cancer-free. But she still takes life one day a time
Click here for the story
Myeloma Patients Flock to Little Rock
Click here for the story
Does a 10-year 10% Continuous Complete Remission Rate for Myeloma Patients Suggest Cure?
Click here for the story
Recent Publications from the Myeloma Institute
TP53 deletion is not an adverse feature in multiple myeloma treated with total therapy 3.
Shaughnessy JD, Zhou Y, Haessler J, van Rhee F, Anaissie E, Nair B, Waheed S, Alsayed Y, Epstein J, Crowley J, Barlogie B.
Br J Haematol. 2009 Aug 21. [Epub ahead of print]. PMID: 19702643.
Gene expression profiling of plasma cells at myeloma relapse from tandem transplantation trial Total Therapy 2 predicts subsequent survival.
Nair B, Shaughnessy JD Jr, Zhou Y, Astrid-Cartron M, Qu P, van Rhee F, Anaissie E, Alsayed Y, Waheed S, Hollmig K, Szymonifka J,
Petty N, Hoering A, Barlogie B.
Blood. 2009;113:6572–6575. PMID: 19389881.
Combinatorial efficacy of anti-CS1 monoclonal antibody elotuzumab (HuLuc63) and bortezomib against multiple myeloma.
van Rhee F, Szmania S, Dillon M, van Abemma A, Li X, Stone M, Garg TK, Shi J, Bost-Moreno A, Yun R, Balasa B, Ganguly B, Chao D,
Rice AG, Zhan F, Shaughnessy J, Barlogie B, Yaccoby S, Afar DEH.
Mol Cancer Ther. 2009;8:2616–2624. PMID: 19723891.
Our specialized and experienced staff provides
superb medical attention in an atmosphere of friendliness and compassion. Our clinical and basic program is unique in creating rapid application of scientific breakthroughs to treating multiple
myeloma patients. The quality of the Myeloma Institute's innovative clinical and basic research is known nationally and internationally.
Dr. Bart Barlogie, M.D., Ph.D.
The Myeloma Institute is headed by Dr. Bart Barlogie, M.D., Ph.D., one of the world’s leading experts in the diagnosis and treatment of multiple myeloma.
Dr. Barlogie and his staff are finding out more
and more about myeloma every day and are committed to finding innovative ways to treat the disease. They refuse to settle for anything less than the best for their patients, just one of the reasons people from all over the world come here for treatment.
The Myeloma Institute for Research and Therapy,
evolving from the breakthrough advances of
the
UAMS
myeloma program, is committed to accelerating curative
therapies for multiple
myeloma and related disease
entities through innovative clinical and basic science
research
and outstanding patient care.
Move your mouse cursor over the image below and click on the play button to view a video vignette about Myeloma research at UAMS featuring Dr. Bart Barlogie. Click here for a larger video.
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